A reliable microinjectrode system for use in behaving monkeys.

ABSTRACT: We describe a modified system for the precise delivery of small volumes of drugs to brain sites of behaving monkeys during simultaneous single-neuron electrophysiology. The system combines a conventional microelectrode for recording single neurons and a small gauge microsyringe in a durable design. It incorporates newly available microfluidic components to achieve high-precision fluidic control. The system is inexpensive, reusable and easy to fabricate; it minimizes neural tissue damage and achieves reliable single-neuron recordings at the injection site.

SUBMITTER: Noudoost B 

PROVIDER: S-EPMC3161729 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature