HMGB1 and cord blood: its role as immuno-adjuvant factor in innate immunity.

ABSTRACT: In newborn the innate immune system provides essential protection during primary infections before the generation of an appropriate adaptive immune response that is initially not fully operative. Innate immune response is evoked and perpetuated by molecules derived from microorganisms or by the damage/death of host cells. These are collectively known as damage-associated molecular-pattern (DAMP) molecules. High-mobility group box 1 protein (HMGB1) or amphoterin, which previously was considered to be only a nuclear factor, has been recently identified as a DAMP molecule. When it is actively secreted by inflammatory cells or passively released from necrotic cells, HMGB1 mediates the response to infection, injury and inflammation, inducing dendritic cells maturation and T helper-1-cell respon

SUBMITTER: Ciucci A 

PROVIDER: S-EPMC3161821 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature