Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.

ABSTRACT: Exposure to influenza viruses is necessary, but not sufficient, for healthy human hosts to develop symptomatic illness. The host response is an important determinant of disease progression. In order to delineate host molecular responses that differentiate symptomatic and asymptomatic Influenza A infection, we inoculated 17 healthy adults with live influenza (H3N2/Wisconsin) and examined changes in host peripheral blood gene expression at 16 timepoints over 132 hours. Here we present distinct transcriptional dynamics of host responses unique to asymptomatic and symptomatic infections. We show that symptomatic hosts invoke, simultaneously, multiple pattern recognition receptors-mediated antiviral and inflammatory responses that may relate to virus-induced oxidative stress. In contrast, asymp

SUBMITTER: Huang Y 

PROVIDER: S-EPMC3161909 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature