Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) has been linked to a state of pre-clinical chronic inflammation resulting from abnormalities in the innate immune pathway. Serum levels of pro-inflammatory cytokines and acute-phase proteins, collectively known as 'inflammatory network', are elevated in the pre-, or early, stages of T2DM and increase with disease progression. Genetic variation can affect the innate immune response to certain environmental factors, and may, therefore, determine an individual's lifetime risk of disease.

Methods

We conducted a cross-sectional study in 6,720 subjects from the Twins UK Registry to evaluate the association between 18 single nucleotide polymorphisms (SNPs) in five genes (TLR4, IL1A, IL6, TNFA, and CRP) along the innate immunity-related inf

SUBMITTER: Arora P 

PROVIDER: S-EPMC3161932 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature