Spatiotemporal expression of SERPINE2 in the human placenta and its role in extravillous trophoblast migration and invasion.

ABSTRACT:

Background

SERPINE2, one of the potent serpins belonging to the plasminogen activator (PA) system, is involved in the tissue remodeling. We previously demonstrated the expression patterns of Serpine2 in the mouse placenta and uterus, indicating that Serpine2 is a major PA inhibitor in the placenta and uterus during the estrous cycle, pregnancy, and lactation. In this study, we further investigated the expression pattern of SERPINE2 in the human placenta and explored possible functional roles of SERPINE2 in regulating trophoblast activity.

Methods

Placental tissues from various trimesters were collected for real-time reverse-transcription polymerase chain reaction quantification. Immunohistochemical staining was performed in placental tissues to assure localization of SERPINE

SUBMITTER: Chern SR 

PROVIDER: S-EPMC3161939 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature