Systematic discovery of unannotated genes in 11 yeast species using a database of orthologous genomic segments.

ABSTRACT:

Background

In standard BLAST searches, no information other than the sequences of the query and the database entries is considered. However, in situations where two genes from different species have only borderline similarity in a BLAST search, the discovery that the genes are located within a region of conserved gene order (synteny) can provide additional evidence that they are orthologs. Thus, for interpreting borderline search results, it would be useful to know whether the syntenic context of a database hit is similar to that of the query. This principle has often been used in investigations of particular genes or genomic regions, but to our knowledge it has never been implemented systematically.

Results

We made use of the synteny information contained in the Yeast Gene

SUBMITTER: OhEigeartaigh SS 

PROVIDER: S-EPMC3161974 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature