Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein.

ABSTRACT: Airway inflammation plays a major role in the pathogenesis of influenza viruses and can lead to a fatal outcome. One of the challenging objectives in the field of influenza research is the identification of the molecular bases associated to the immunopathological disorders developed during infection. While its precise function in the virus cycle is still unclear, the viral protein PB1-F2 is proposed to exert a deleterious activity within the infected host. Using an engineered recombinant virus unable to express PB1-F2 and its wild-type homolog, we analyzed and compared the pathogenicity and host response developed by the two viruses in a mouse model. We confirmed that the deletion of PB1-F2 renders the virus less virulent. The global transcriptomic analyses of the infected lungs revealed a

SUBMITTER: Le Goffic R 

PROVIDER: S-EPMC3161975 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature