Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.

ABSTRACT: African Americans have been understudied in genome wide association studies of diabetes and related traits. In the current study, we examined the joint association of single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) with fasting insulin and an index of insulin resistance (HOMA-IR) in the HyperGEN study, a family based study with proband ascertainment for hypertension. This analysis is restricted to 1,040 African Americans without diabetes. We generated allele specific CNV genotypes at 872,243 autosomal loci using Birdsuite, a freely available multi-stage program. Joint tests of association for SNPs and CNVs were performed using linear mixed models adjusting for covariates and familial relationships. Our results highlight SNPs associated with fasting insulin and HOMA-I

SUBMITTER: Irvin MR 

PROVIDER: S-EPMC3162025 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature