Candidate gene studies in gallbladder cancer: a systematic review and meta-analysis.

ABSTRACT: Gallbladder cancer (GBC) is the most frequent biliary tract malignancy. Wide variations in GBC incidence and familial and epidemiological data suggest involvement of a genetic component in its etiopathogenesis. A systematic review of genetic association studies in GBC was performed by applying a meta-analysis approach and systematically reviewing PubMed database using appropriate terms. Odds ratios (ORs) and 95% confidence intervals (CIs) were appropriately derived for each gene-disease association using fixed and random effect models. Meta-regression with population size and genotyping method was also performed. Study quality was assessed using a 10-point scoring system designed from published guidelines. Following a review of 44 published manuscripts and one unpublished report, 80 candid

SUBMITTER: Srivastava K 

PROVIDER: S-EPMC3162044 | biostudies-literature | 2011 Jul-Oct

REPOSITORIES: biostudies-literature