An initial study of neural responses to monetary incentives as related to treatment outcome in cocaine dependence.

ABSTRACT:

Background

Although cocaine dependence (CD) involves abnormalities in drug-related, reward-based decision making, it is not well understood whether these abnormalities generalize to nondrug-related cues and rewards and how neural functions underlying reward processing in cocaine abusers relate to treatment outcome.

Methods

Twenty CD patients before treatment and 20 matched healthy control (HC) subjects participated in functional magnetic resonance imaging while performing a monetary incentive delay task. Outcomes through 8 weeks were assessed via percent cocaine-negative urine toxicology, self-reported cocaine abstinence, and treatment retention.

Results

Among the whole sample, anticipation of working for monetary reward (i.e., reward anticipation) was associated with

SUBMITTER: Jia Z 

PROVIDER: S-EPMC3162064 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature