C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis.

ABSTRACT:

Background

Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances.

Methods

We meta-analysed individual records of 160 309 people without a history of vascular disease (ie, 1.31 million person-years at risk, 27 769 fatal or non-fatal disease outcomes) from 54 long-term prospective studies. Within-study regression analyses were adjusted for within-person variation in risk factor levels.

Results

Log(e) CRP concentration was linearly associated with several conventional risk factors and inflammatory markers, and nearly log-linearly with

SUBMITTER: Emerging Risk Factors Collaboration 

PROVIDER: S-EPMC3162187 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature