Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats.

ABSTRACT:

Background

Serum IGF-I and IGF-II levels decline with age. IGF-I replacement therapy reduces the impact of age in rats. We have recently reported that IGF-II is able to act, in part, as an analogous of IGF-I in aging rats reducing oxidative damage in brain and liver associated with a normalization of antioxidant enzyme activities. Since mitochondria seem to be the most important cellular target of IGF-I, the aim of this work was to investigate whether the cytoprotective actions of IGF-II therapy are mediated by mitochondrial protection.

Methods

Three groups of rats were included in the experimental protocol young controls (17 weeks old); untreated old rats (103 weeks old); and aging rats (103 weeks old) treated with IGF-II (2 μg/100 g body weight and day) for 30 days.

Res

SUBMITTER: Garcia-Fernandez M 

PROVIDER: S-EPMC3162510 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature