HIV-1 mutational pathways under multidrug therapy.

ABSTRACT:

Background

Genotype-derived drug resistance profiles are a valuable asset in HIV-1 therapy decisions. Therapy decisions could be further improved, both in terms of predicting length of current therapy success and in preserving followup therapy options, through better knowledge of mutational pathways- here defined as specific locations on the viral genome which, when mutant, alter the risk that additional specific mutations arise. We limit the search to locations in the reverse transcriptase region of the HIV-1 genome which host resistance mutations to nucleoside (NRTI) and non-nucleoside (NNRTI) reverse transcriptase inhibitors (as listed in the 2008 International AIDS Society report), or which were mutant at therapy start in 5% or more of the therapies studied.

Methods

A Co

SUBMITTER: Lawyer G 

PROVIDER: S-EPMC3162516 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature