Longitudinal changes of structural connectivity in traumatic axonal injury.

ABSTRACT:

Objectives

To identify structural connectivity change occurring during the first 6 months after traumatic brain injury and to evaluate the utility of diffusion tensor tractography for predicting long-term outcome.

Methods

The participants were 28 patients with mild to severe traumatic axonal injury and 20 age- and sex-matched healthy control subjects. Neuroimaging was obtained 0-9 days postinjury for acute scans and 6-14 months postinjury for chronic scans. Long-term outcome was evaluated on the day of the chronic scan. Twenty-eight fiber regions of 9 major white matter structures were reconstructed, and reliable tractography measurements were determined and used.

Results

Although most (23 of 28) patients had severe brain injury, their long-term outcome ranged from go

SUBMITTER: Wang JY 

PROVIDER: S-EPMC3162636 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature