Altered functional connectivity in asymptomatic MAPT subjects: a comparison to bvFTD.

ABSTRACT:

Objective

To determine whether functional connectivity is altered in subjects with mutations in the microtubule associated protein tau (MAPT) gene who were asymptomatic but were destined to develop dementia, and to compare these findings to those in subjects with behavioral variant frontotemporal dementia (bvFTD).

Methods

In this case-control study, we identified 8 asymptomatic subjects with mutations in MAPT and 8 controls who screened negative for mutations in MAPT. Twenty-one subjects with a clinical diagnosis of bvFTD were also identified and matched to 21 controls. All subjects had resting-state fMRI. In-phase functional connectivity was assessed between a precuneus seed in the default mode network (DMN) and a fronto-insular cortex seed in the salience network, and the

SUBMITTER: Whitwell JL 

PROVIDER: S-EPMC3162637 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature