Network correlates of the cognitive response to levodopa in Parkinson disease.

ABSTRACT:

Objective

Cognitive dysfunction is common in Parkinson disease (PD), even early in its clinical course. This disease manifestation has been associated with impaired verbal learning performance as well as abnormal expression of a specific PD-related cognitive spatial covariance pattern (PDCP). It is not known, however, how this metabolic network relates to the cognitive response to dopaminergic therapy on the individual patient level.

Methods

We assessed treatment-mediated changes in verbal learning and PDCP expression in 17 patients with PD without dementia who underwent cognitive testing and metabolic imaging in the unmedicated and levodopa-treated conditions. We also determined whether analogous changes were present in 12 other patients with PD without dementia who were ev

SUBMITTER: Mattis PJ 

PROVIDER: S-EPMC3162641 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature