Differential gene expression in Schistosoma japonicum schistosomula from Wistar rats and BALB/c mice.

ABSTRACT:

Background

More than 46 species of mammals can be naturally infected with Schistosoma japonicum in the mainland of China. Mice are permissive and may act as the definitive host of the life cycle. In contrast, rats are less susceptible to S. japonicum infection, and are considered to provide an unsuitable micro-environment for parasite growth and development. Since little is known of what effects this micro-environment has on the parasite itself, we have in the present study utilised a S. japonicum oligonucleotide microarray to compare the gene expression differences of 10-day-old schistosomula maintained in Wistar rats with those maintained in BALB/c mice.

Results

In total 3,468 schistosome genes were found to be differentially expressed, of which the majority (3,335) were d

SUBMITTER: Peng J 

PROVIDER: S-EPMC3162926 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature