Molecular evolution of cyclin proteins in animals and fungi.

ABSTRACT:

Background

The passage through the cell cycle is controlled by complexes of cyclins, the regulatory units, with cyclin-dependent kinases, the catalytic units. It is also known that cyclins form several families, which differ considerably in primary structure from one eukaryotic organism to another. Despite these lines of evidence, the relationship between the evolution of cyclins and their function is an open issue. Here we present the results of our study on the molecular evolution of A-, B-, D-, E-type cyclin proteins in animals and fungi.

Results

We constructed phylogenetic trees for these proteins, their ancestral sequences and analyzed patterns of amino acid replacements. The analysis of infrequently fixed atypical amino acid replacements in cyclins evidenced that accel

SUBMITTER: Gunbin KV 

PROVIDER: S-EPMC3162929 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature