Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.

ABSTRACT:

Background

Elevated levels of factor VIII (FVIII) and von Willebrand Factor (vWF) are well-established risk factors for cardiovascular diseases, in particular venous thrombosis. Although high, the heritability of these traits is poorly explained by the genetic factors known so far. The aim of this work was to identify novel single nucleotide polymorphisms (SNPs) that could influence the variability of these traits.

Methods

Three independent genome-wide association studies for vWF plasma levels and FVIII activity were conducted and their results were combined into a meta-analysis totalling 1,624 subjects.

Results

No single nucleotide polymorphism (SNP) reached the study-wide significance level of 1.12 × 10-7 that corresponds to the Bonferroni correction for the number

SUBMITTER: Antoni G 

PROVIDER: S-EPMC3163514 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature