Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription.

ABSTRACT:

Background

Artemisinin resistance in Plasmodium falciparum malaria has emerged in Western Cambodia. This is a major threat to global plans to control and eliminate malaria as the artemisinins are a key component of antimalarial treatment throughout the world. To identify key features associated with the delayed parasite clearance phenotype, we employed DNA microarrays to profile the physiological gene expression pattern of the resistant isolates.

Results

In the ring and trophozoite stages, we observed reduced expression of many basic metabolic and cellular pathways which suggests a slower growth and maturation of these parasites during the first half of the asexual intraerythrocytic developmental cycle (IDC). In the schizont stage, there is an increased expression of essenti

SUBMITTER: Mok S 

PROVIDER: S-EPMC3163569 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature