Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas.

ABSTRACT:

Background

High serum levels of estradiol are associated with increased risk of postmenopausal breast cancer. Little is known about the gene expression in normal breast tissue in relation to levels of circulating serum estradiol.

Methods

We compared whole genome expression data of breast tissue samples with serum hormone levels using data from 79 healthy women and 64 breast cancer patients. Significance analysis of microarrays (SAM) was used to identify differentially expressed genes and multivariate linear regression was used to identify independent associations.

Results

Six genes (SCGB3A1, RSPO1, TLN2, SLITRK4, DCLK1, PTGS1) were found differentially expressed according to serum estradiol levels (FDR = 0). Three of these independently predicted estradiol levels in a

SUBMITTER: Haakensen VD 

PROVIDER: S-EPMC3163631 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature