Repression of human activation induced cytidine deaminase by miR-93 and miR-155.

ABSTRACT:

Background

Activation Induced cytidine Deaminase (AID) targets the immunoglobulin genes of activated B cells, where it converts cytidine to uracil to induce mutagenesis and recombination. While essential for immunoglobulin gene diversification, AID misregulation can result in genomic instability and oncogenic transformation. This is classically illustrated in Burkitt's lymphoma, which is characterized by AID-induced mutation and reciprocal translocation of the c-MYC oncogene with the IgH loci. Originally thought to be B cell-specific, AID now appears to be misexpressed in several epithelial cancers, raising the specter that AID may also participate in non-B cell carcinogenesis.

Methods

The mutagenic potential of AID argues for the existence of cellular regulators capable of

SUBMITTER: Borchert GM 

PROVIDER: S-EPMC3163633 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature