Sleeve gastrectomy in rats improves postprandial lipid clearance by reducing intestinal triglyceride secretion.

ABSTRACT:

Background & aims

Postprandial hyperlipidemia is a risk factor for atherosclerotic heart disease and is associated with the consumption of high-fat diets and obesity. Bariatric surgeries result in superior and more durable weight loss than dieting. These surgeries are also associated with multiple metabolic improvements, including reduced plasma lipid levels. We investigated whether the beneficial effects of vertical sleeve gastrectomy (VSG) on plasma lipid levels are weight independent.

Methods

VSG was performed on Long-Evans rats with diet-induced obesity. Controls were sham-operated animals who were either pair-fed or ad libitum-fed. We measured fasting and postprandial levels of plasma lipid. To determine hepatic and intestinal triglyceride secretion, we injected the lip

SUBMITTER: Stefater MA 

PROVIDER: S-EPMC3163733 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature