Expression of duck CCL19 and CCL21 and CCR7 receptor in lymphoid and influenza-infected tissues.

ABSTRACT: Ducks are the natural host and reservoir of influenza viruses. We are interested in their immune responses to these viruses, to understand host-pathogen interactions and to develop effective agricultural vaccines. We identified duck homologues of the chemokines CCL19 and CCL21 and cloned their cognate receptor, CCR7. Conservation of key features, and expression in lymphoid tissues suggests that these chemokines are the direct orthologues of their mammalian counterparts. Mammalian CCL19 and CCL21 are responsible for the homing of dendritic cells and naïve lymphocytes to secondary lymphoid tissues. The contribution of local tertiary lymphoid tissues may be important during influenza infection in ducks. Consistent with leukocyte recruitment, CCL19 and CCL21 transcripts are abundant in lung ti

SUBMITTER: Fleming-Canepa X 

PROVIDER: S-EPMC3163774 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature