Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis.

ABSTRACT:

Aims

The cascade of events leading to compromised mitochondrial integrity in response to stress is mediated by various combinatorial interactions of pro- and anti-apoptotic molecules. Nur77, an immediate early gene that encodes a nuclear orphan receptor, translocates from the nucleus to mitochondria to induce cytochrome c release and apoptosis in cancer cells in response to various pro-apoptotic treatments. However, the role of Nur77 in the cardiac setting is still unclear. The objective of this study is to determine the physiological relevance and pathophysiological importance of Nur77 in cardiomyocytes.

Methods and results

Myocardial Nur77 is upregulated following cardiomyopathic injury and, while expressed in the postnatal myocardium, declines in level within weeks after

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC3164102 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature