Identification of candidate genes related to bovine marbling using protein-protein interaction networks.

ABSTRACT: Complex traits are determined by the combined effects of many loci and are affected by gene networks or biological pathways. Systems biology approaches have an important role in the identification of candidate genes related to complex diseases or traits at the system level. The present study systemically analyzed genes associated with bovine marbling score and identified their relationships. The candidate nodes were obtained using MedScan text-mining tools and linked by protein-protein interaction (PPI) from the Human Protein Reference Database (HPRD). To determine key node of marbling, the degree and betweenness centrality (BC) were used. The hub nodes and biological pathways of our network are consistent with the previous reports about marbling traits, and also suggest unknown candidate

SUBMITTER: Lim D 

PROVIDER: S-EPMC3164149 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature