Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis.

ABSTRACT:

Background

A common genotypic basis for ulcerative colitis (UC) and Crohn's disease (CD) is implied by overlapping clinical characteristics, epidemiological studies, and association of genes with both UC and CD. We evaluated the overlap between CD and UC genetic loci stratified by pathogenetic pathways and by disease location.

Methods

The allele frequencies of six UC-associated and 34 CD-associated single nucleotide polymorphisms (SNPs) were determined in a Canadian IBD cohort (n = 2374). Differences between CD, UC, colon-only CD, ileal CD, and controls were analyzed controlling for ethnicity, age of diagnosis, and gender.

Results

In all, 21 of 34 CD-associated SNPs had similar allele frequencies in UC (n = 1230) and CD (n = 1144). Three of six UC-associated SNPs had

SUBMITTER: Waterman M 

PROVIDER: S-EPMC3164287 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature