The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans.

ABSTRACT: Cell invasion through basement membrane is a specialized cellular behavior critical for many developmental processes and leukocyte trafficking. Invasive cellular behavior is also inappropriately co-opted during cancer progression. Acquisition of an invasive phenotype is accompanied by changes in gene expression that are thought to coordinate the steps of invasion. The transcription factors responsible for these changes in gene expression, however, are largely unknown. C. elegans anchor cell (AC) invasion is a genetically tractable in vivo model of invasion through basement membrane. AC invasion requires the conserved transcription factor FOS-1A, but other transcription factors are thought to act in parallel to FOS-1A to control invasion. Here we identify the transcription factor HLH-2, the

SUBMITTER: Schindler AJ 

PROVIDER: S-EPMC3164387 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature