Distinct profiles of brain and cognitive changes in the very old with Alzheimer disease.

ABSTRACT:

Objective

To determine whether age-standardized brain morphometric and cognitive profiles differ in young-old (aged 60-75 years) and very-old (aged 80-91 years) patients with Alzheimer disease (AD).

Methods

Using a case-control retrospective design, we compared hippocampal volume and cortical gray matter thickness in areas known to be affected by AD in 105 patients with AD and 125 healthy control (HC) participants divided into young-old and very-old subgroups. Brain morphometric and cognitive scores of the AD groups were standardized to their respective age-appropriate HC subgroup and then compared.

Results

Several cognitive domains (executive function, immediate memory, and attention/processing speed) were less abnormal in the very old with AD than in the young old w

SUBMITTER: Stricker NH 

PROVIDER: S-EPMC3164395 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature