The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration.

ABSTRACT: The NF-κB family of transcription factors is a well-established regulator of the immune and inflammatory responses and also plays a key role in other cellular processes, including cell death, proliferation, and migration. Conserved residues in the trans-activation domain of RelA, which can be posttranslationally modified, regulate divergent NF-κB functions in response to different cellular stimuli. Using rela(-/-) mouse embryonic fibroblasts reconstituted with RelA, we find that mutation of the threonine 505 (T505) phospho site to alanine has wide-ranging effects on NF-κB function. These include previously described effects on chemotherapeutic drug-induced apoptosis, as well as new roles for this modification in autophagy, cell proliferation, and migration. This last effect was associated

SUBMITTER: Msaki A 

PROVIDER: S-EPMC3164452 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature