Contingency management and levodopa-carbidopa for cocaine treatment: a comparison of three behavioral targets.

ABSTRACT: New data support use of levodopa pharmacotherapy with behavioral contingency management (CM) as one efficacious combination in cocaine dependence disorder treatment. A potential mechanism of the combined treatment effects may be related to dopamine-induced enhancement of the saliency of contingently delivered reinforcers. Evidence to support this mechanism was sought by evaluating levodopa-enhancing effects across distinct CM conditions that varied in behavioral targets. A total of 136 treatment-seeking, cocaine dependent subjects participated in this 12-week, randomized, placebo-controlled trial of levodopa (vs. placebo) administered in combination with one of three behavioral CM conditions. In the CM-URINE condition, subjects received cash-valued vouchers contingent on cocaine-negative u

SUBMITTER: Schmitz JM 

PROVIDER: S-EPMC3164487 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature