Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk.

ABSTRACT:

Purpose

Five genetic variants along chromosomes 8q24 and 17q have a cumulative association with prostate cancer risk. Our research group previously reported an association between these variants and clinicopathological characteristics. More recently 4 additional prostate cancer susceptibility variants were identified on chromosomes 2p15, 10q11, 11q13 and Xp11. We performed cumulative risk assessment incorporating all 9 genetic variants and determined the relationship of the new variants to clinicopathological tumor features.

Materials and methods

The genotype of 9 variants was determined in 687 men of European ancestry who underwent radical prostatectomy from 2002 to 2008 and in 777 healthy volunteer controls. We compared the incidence of these variants in prostate cancer ca

SUBMITTER: Helfand BT 

PROVIDER: S-EPMC3164535 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature