Enhanced Inter-helical Residue Contact Prediction in Transmembrane Proteins.

ABSTRACT: In this paper, based on a recent work by McAllister and Floudas who developed a mathematical optimization model to predict the contacts in transmembrane alpha-helical proteins from a limited protein data set [1], we have enhanced this method by 1) building a more comprehensive data set for transmembrane alpha-helical proteins and this enhanced data set is then used to construct the probability sets, MIN-1N and MIN-2N, for residue contact prediction, 2) enhancing the mathematical model via modifications of several important physical constraints and 3) applying a new blind contact prediction scheme on different protein sets proposed from analyzing the contact prediction on 65 proteins from Fuchs et al. [2]. The blind contact prediction scheme has been tested on two different membrane protein

SUBMITTER: Wei Y 

PROVIDER: S-EPMC3164537 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature