Reversibility of adverse, calcineurin-dependent cardiac remodeling.

ABSTRACT:

Rationale

Studies to dissect the role of calcineurin in pathological cardiac remodeling have relied heavily on murine models, in which genetic gain- and loss-of-function manipulations are initiated at or before birth. However, the great majority of clinical cardiac pathology occurs in adults. Yet nothing is known about the effects of calcineurin when its activation commences in adulthood. Furthermore, despite the fact that ventricular hypertrophy is a well-established risk factor for heart failure, the relative pace and progression of these 2 major phenotypic features of heart disease are unknown. Finally, even though therapeutic interventions in adults are designed to slow, arrest, or reverse disease pathogenesis, little is known about the capacity for spontaneous reversibility of

SUBMITTER: Berry JM 

PROVIDER: S-EPMC3164792 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature