Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress.

ABSTRACT:

Background

Glutathione S-transferase pi (GSTPi) is the predominant redox regulator in the lung. Although evidence implicates an important role for GSTPi in asthma, the mechanism for this has remained elusive.

Objectives

We sought to determine how GSTPi is regulated in asthma and to elucidate its role in maintaining redox homeostasis.

Methods

We elucidated the regulation of GSTPi in children with asthma and used murine models of asthma to determine the role of GSTPi in redox homeostasis.

Results

Our findings demonstrate that GSTPi transcript levels are markedly downregulated in allergen- and IL-13-treated murine models of asthma through signal transducer and activator of transcription 6-dependent and independent pathways. Nuclear factor erythroid 2-related facto

SUBMITTER: Schroer KT 

PROVIDER: S-EPMC3164907 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature