Harmonin inhibits presynaptic Cav1.3 Ca²⁺ channels in mouse inner hair cells.

ABSTRACT: Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca(2+) channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.

SUBMITTER: Gregory FD 

PROVIDER: S-EPMC3164920 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature