Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation.

ABSTRACT:

Background

Asthma in obese subjects is poorly understood, and these patients are often refractory to standard therapy.

Objectives

We sought to gain insights into the pathogenesis and treatment of asthma in obese subjects by determining how obesity and bariatric surgery affect asthma control, airway hyperresponsiveness (AHR), and markers of asthmatic inflammation.

Methods

We performed a prospective study of (1) asthmatic and nonasthmatic patients undergoing bariatric surgery compared at baseline and (2) asthmatic patients followed for 12 months after bariatric surgery.

Results

We studied 23 asthmatic and 21 nonasthmatic patients undergoing bariatric surgery. At baseline, asthmatic patients had lower FEV(1) and forced vital capacity and lower numbers of lymphocyt

SUBMITTER: Dixon AE 

PROVIDER: S-EPMC3164923 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature