Enantioselective acylation of silyl ketene acetals through fluoride anion-binding catalysis.

ABSTRACT: A highly enantioselective acylation of silyl ketene acetals with acyl fluorides has been developed to generate useful α,α-disubstituted butyrolactone products. This transformation is promoted by a new thiourea catalyst and 4-pyrrolidinopyridine and represents the first example of enantioselective thiourea anion-binding catalysis with fluoride.

SUBMITTER: Birrell JA 

PROVIDER: S-EPMC3164931 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature