Systemic and mucosal differences in HIV burden, immune, and therapeutic responses.

ABSTRACT:

Background

Mucosal tissues represent major targets for HIV transmission but differ in susceptibility and reservoir function by unknown mechanisms.

Methods

In a cross-sectional study, HIV RNA and infectious virus were compared between oral and genital compartments and blood in HIV-infected women, in association with clinical parameters, copathogens, and putative innate and adaptive HIV inhibitors.

Results

HIV RNA was detectable in 24.5% of women from all 3 compartments, whereas 45% had RNA in only 1 or 2 sites. By comparison, infectious HIV, present in blood of the majority, was rare in mucosal sites. Innate mediators, secretory leukocyte protease inhibitor and thrombospondin, were highest in mucosae. Highly active antiretroviral therapy was associated with an 80% decr

SUBMITTER: Wahl SM 

PROVIDER: S-EPMC3164950 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature