Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions.

ABSTRACT: The inhibition of protein-protein interactions and their ensuing signaling processes play an increasingly important role in modern medicine. Small molecular-weight inhibitors that can be administered orally are the preferred approach but efficient strategies for developing them are not yet generally available. Due to the large size difference between the protein-protein interface and the small molecule, inhibitor interactions are expected to extend to only a small region of the interface. If this is the case, classical competitive inhibition may be hard to achieve. In addition, competitive inhibition wastes binding energy that can be effectively used to inhibit signaling. The best and most energy-efficient approach would be the development of small molecules that bind at the protein-protei

SUBMITTER: Schon A 

PROVIDER: S-EPMC3164996 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature