Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.

ABSTRACT: Genetic influences that underlie spontaneous lung oncogenesis are poorly understood. The objective of this study was to determine the genetic influences on spontaneous pulmonary adenoma frequency and severity in 28 strains of mice as part of a large-scale aging study conducted at the Jackson Aging Center (http://agingmice.jax.org/). Genome-wide association studies were conducted in these strains with both low-density (132,000) and high-density (4,000,000) panel of single-nucleotide polymorphisms (SNP). Our analysis revealed that adenomas were relatively less frequent and less severe in females than males, and that loci implicated in frequency and severity were often different between male and female mice. While some of the significant loci identified mapped to genomic locations known to be

SUBMITTER: Berndt A 

PROVIDER: S-EPMC3165088 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature