Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida.

ABSTRACT: Respiratory tract infections in cattle are commonly associated with the bacterial pathogens Mannheimia haemolytica and Pasteurella multocida. These infections can generally be successfully treated in the field with one of several groups of antibiotics, including macrolides. A few recent isolates of these species exhibit resistance to veterinary macrolides with phenotypes that fall into three distinct classes. The first class has type I macrolide, lincosamide, and streptogramin B antibiotic resistance and, consistent with this, the 23S rRNA nucleotide A2058 is monomethylated by the enzyme product of the erm(42) gene. The second class shows no lincosamide resistance and lacks erm(42) and concomitant 23S rRNA methylation. Sequencing of the genome of a representative strain from this class, P.

SUBMITTER: Desmolaize B 

PROVIDER: S-EPMC3165316 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature