A molecular basis for tungstate selectivity in prokaryotic ABC transport systems.

ABSTRACT: The essential trace compounds tungstate and molybdate are taken up by cells via ABC transporters. Despite their similar ionic radii and chemical properties, the WtpA protein selectively binds tungstate in the presence of molybdate. Using site-directed mutagenesis of conserved binding pocket residues, we established a molecular basis for tungstate selectivity.

SUBMITTER: Bevers LE 

PROVIDER: S-EPMC3165707 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature