Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host.

ABSTRACT:

Background

The infective schistosome cercaria develops within the intramolluscan daughter sporocyst from an undifferentiated germ ball, during which synthesis of proteins essential for infection occurs. When the aquatic cercaria locates the mammalian host it rapidly penetrates into the epidermis using glandular secretions. It then undergoes metamorphosis into the schistosomulum, including replacement of its tegument surface membranes, a process taking several days before it exits the skin. Patterns of gene expression underlying this transition have been characterised.

Methods and principal findings

All gene models from the S. mansoni genome (www.GeneDB.org) were incorporated into a high-density oligonucleotide array. Double-stranded cDNA from germ balls, cercariae, and day 3

SUBMITTER: Parker-Manuel SJ 

PROVIDER: S-EPMC3166049 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature