Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China.

ABSTRACT:

Background

Breast cancer is a polygenetic disorder with a complex inheritance pattern. Single nucleotide polymorphisms (SNPs), the most common genetic variations, influence not only phenotypic traits, but also interindividual predisposition to disease, treatment outcomes with drugs and disease prognosis. The co-stimulatory molecule CD40 plays a prominent role in immune regulation and homeostasis. Accumulating evidence suggests that CD40 contributes to the pathogenesis of cancer. Here, we set out to test the association between polymorphisms in the CD40 gene and breast carcinogenesis and tumor pathology.

Methodology and principal findings

Four SNPs (rs1800686, rs1883832, rs4810485 and rs3765459) were genotyped by the polymerase chain reaction restriction fragment length polym

SUBMITTER: Shuang C 

PROVIDER: S-EPMC3166053 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature