The glial regenerative response to central nervous system injury is enabled by pros-notch and pros-NFκB feedback.

ABSTRACT: Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NFκB. Together they main

SUBMITTER: Kato K 

PROVIDER: S-EPMC3166069 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature