The interplay between tubulins and P450 cytochromes during Plasmodium berghei invasion of Anopheles gambiae midgut.

ABSTRACT:

Background

Plasmodium infection increases the oxidative stress inside the mosquito, leading to a significant alteration on transcription of Anopheles gambiae detoxification genes. Among these detoxification genes several P450 cytochromes and tubulins were differently expressed, suggesting their involvement in the mosquito's response to parasite invasion. P450 cytochromes are usually involved in the metabolism and detoxification of several compounds, but are also regulated by several pathogens, including malaria parasite. Tubulins are extremely important as components of the cytoskeleton, which rearrangement functions as a response to malaria parasite invasion.

Methodology/principal findings

Gene silencing methods were used to uncover the effects of cytochrome P450 reductase,

SUBMITTER: Felix RC 

PROVIDER: S-EPMC3166158 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature