Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.

ABSTRACT:

Background

The presence of cancer-specific DNA methylation patterns in epithelial colorectal cells in human feces provides the prospect of a simple, non-invasive screening test for colorectal cancer and its precursor, the adenoma. This study investigates a panel of epigenetic markers for the detection of colorectal cancer and adenomas.

Methods

Candidate biomarkers were subjected to quantitative methylation analysis in test sets of tissue samples from colorectal cancers, adenomas, and normal colonic mucosa. All findings were verified in independent clinical validation series. A total of 523 human samples were included in the study. Receiver operating characteristic (ROC) curve analysis was used to evaluate the performance of the biomarker panel.

Results

Promoter hyperm

SUBMITTER: Lind GE 

PROVIDER: S-EPMC3166273 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature