Synaptosomal-associated protein 25 gene polymorphisms and antisocial personality disorder: association with temperament and psychopathy.

ABSTRACT:

Objective

The molecular genetic of personality disorders has been investigated in several studies; however, the association of antisocial behaviours with synaptosomal-associated protein 25 (SNAP25) gene polymorphisms has not. This association is of interest as SNAP25 gene polymorphism has been associated with attention-deficit hyperactivity disorder and personality.

Methods

We compared the distribution of DdeI and MnII polymorphisms in 91 young male offenders and in 38 sex-matched healthy control subjects. We also investigated the association of SNAP25 gene polymorphisms with severity of psychopathy and with temperament traits: novelty seeking, harm avoidance, and reward dependence.

Results

The MnII T/T and DdeI T/T genotypes were more frequently present in male subje

SUBMITTER: Basoglu C 

PROVIDER: S-EPMC3166635 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature