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Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.

ABSTRACT: The RGS1 gene is associated with celiac disease, multiple sclerosis, and type I diabetes, which are all T cell-mediated pathologies, yet there is no reported analysis of regulator of G protein signaling (RGS)1 biology in human T cells. This study shows that RGS1 expression is substantially higher in T cells from human gut versus peripheral blood and that this can be exaggerated in intestinal inflammation. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines, whereas RGS1 depletion selectively enhances such chemotaxis in gut T cells and impairs their colitogenic potential. These findings provide a revised framework in which to view the linkage of RGS1 to inflammatory disease.

SUBMITTER: Gibbons DL 

PROVIDER: S-EPMC3166702 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Cutting Edge: Regulator of G protein signaling-1 selectively regulates gut T cell trafficking and colitic potential.

Gibbons Deena L DL   Abeler-Dörner Lucie L   Raine Tim T   Hwang Il-Young IY   Jandke Anett A   Wencker Melanie M   Deban Livija L   Rudd Christopher E CE   Irving Peter M PM   Kehrl John H JH   Hayday Adrian C AC  

Journal of immunology (Baltimore, Md. : 1950) 20110727 5

The RGS1 gene is associated with celiac disease, multiple sclerosis, and type I diabetes, which are all T cell-mediated pathologies, yet there is no reported analysis of regulator of G protein signaling (RGS)1 biology in human T cells. This study shows that RGS1 expression is substantially higher in T cells from human gut versus peripheral blood and that this can be exaggerated in intestinal inflammation. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines, wher  ...[more]